Blar i forfatter "Rounge, Trine Ballestad"

Viser treff 1-13 av 13

    • Accurate microRNA annotation of animal genomes using trained covariance models of curated microRNA complements in MirMachine 

      Umu, Sinan Ugur; Paynter, Vanessa Molin; Trondsen, Håvard; Buschmann, Tilo; Rounge, Trine Ballestad; Peterson, Kevin J.; Fromm, Bastian (Journal article; Tidsskriftartikkel; Peer reviewed, 2023-06-23)
      The annotation of microRNAs depends on the availability of transcriptomics data and expert knowledge. This has led to a gap between the availability of novel genomes and high-quality microRNA complements. Using >16,000 microRNAs from the manually curated microRNA gene database MirGeneDB, we generated trained covariance models for all conserved microRNA families. These models are available in our ...

    • Associations of the 2018 World Cancer Research Fund/American Institute of Cancer Research (WCRF/AICR) cancer prevention recommendations with stages of colorectal carcinogenesis 

      Kværner, Ane Sørlie; Andersen, Astrid Riseth; Henriksen, Hege Berg; Knudsen, Markus Dines; Johansen, Anne Marte Wetting; Hjartåker, Anette; Bøhn, Siv Kjølsrud; Paur, Ingvild; Wiedswang, Gro; Smeland, Sigbjørn; Rounge, Trine Ballestad; Blomhoff, Rune; Berstad, Paula (Journal article; Tidsskriftartikkel; Peer reviewed, 2023-05-22)
      Background: While adherence to cancer prevention recommendations is linked to lower risk of colorectal cancer (CRC), few have studied associations across the entire spectrum of colorectal carcinogenesis. Here, we studied the relationship of the standardized 2018 World Cancer Research Fund/American Institute for Cancer Research (WCRF/AICR) Score for cancer prevention recommendations with detection ...

    • Cisplatin treatment of testicular cancer patients introduces long-term changes in the epigenome 

      Bucher-Johannessen, Cecilie; Page, Christian Magnus; Haugen, Trine B.; Wojewodzic, Marcin; Fosså, Sophie Dorothea; Grotmol, Tom; Haugnes, Hege Sagstuen; Rounge, Trine Ballestad (Journal article; Tidsskriftartikkel; Peer reviewed, 2019-12-03)
      <i>Background</i> - Cisplatin-based chemotherapy (CBCT) is part of standard treatment of several cancers. In testicular cancer (TC) survivors, an increased risk of developing metabolic syndrome (MetS) is observed. In this epigenome-wide association study, we investigated if CBCT relates to epigenetic changes (DNA methylation) and if epigenetic changes render individuals susceptible for developing ...

    • Cohort Profile: The Finnish Health in Teens (Fin-HIT) study: A population-based study 

      Figueiredo, Rejane Augusta de Oliveira; Simola-Ström, Sabina; Rounge, Trine Ballestad; Viljakainen, Heli; Eriksson, Johan G.; Roos, Eva; Weiderpass, Elisabete (Journal article; Tidsskriftartikkel; Peer reviewed, 2018-09-12)
      The prevalence of overweight and obesity in children and adolescents is increasing globally. In high-income countries, the prevalence of obesity has plateaued, although the rate is still high. Children with overweight and obesity are likely to stay obese into adulthood and tend to develop certain diseases, such as pulmonary, cardiovascular and metabolic diseases, more frequently and at a younger ...

    • Eating habits and weight status in Finnish adolescents 

      Viljakainen, Jannina; Figueiredo, Rejane Augusta de Oliveira; Viljakainen, Heli; Roos, Eva; Weiderpass, Elisabete; Rounge, Trine Ballestad (Journal article; Tidsskriftartikkel; Peer reviewed, 2019-06-21)
      <i>Objective</i>: To investigate the association between eating habits and weight status in adolescents in Finland.<p><p> <i>Design</i>: Cross-sectional study.<p><p> <i>Setting</i>: The Finnish Health in Teens (Fin-HIT) study is a cohort study conducted in adolescents attending third to sixth grade in 496 schools in forty-four municipalities in Southern, Middle and Northern Finland in ...

    • Gender-specific associations between saliva microbiota and body size 

      Raju, Sajan C.; Lagström, Sonja; Ellonen, Pekka; de Vos, Willem M.; Eriksson, Johan G.; Weiderpass, Elisabete; Rounge, Trine Ballestad (Journal article; Tidsskriftartikkel; Peer reviewed, 2019-04-10)
      <i>Objective</i>: The human intestinal microbiota likely play an important role in the development of overweight and obesity. However, the associations between saliva microbiota and body mass index (BMI) have been sparsely studied. The aim of this study was to identify the associations between saliva microbiota and body size in Finnish children.<p> <p><i>Methods</i>: The saliva microbiota of ...

    • The genome sequence of Atlantic cod reveals a unique immune system 

      Star, Bastiaan; Nederbragt, Alexander Johan; Jentoft, Sissel; Grimholt, Unni; Malmstrøm, Martin; Gregers, Tone Fredsvik; Rounge, Trine Ballestad; Paulsen, Jonas; Solbakken, Monica Hongrø; Sharma, Animesh; Wetten, Ola Frang; Lanzén, Anders; Winer, Roger; Knight, James; Vogel, Jan-Hinnerk; Aken, Bronwen; Andersen, Øivind; Lagesen, Karin; Tooming-Klunderud, Ave; Edvardsen, Rolf; Kirubakaran, G. Tina; Espelund, Mari; Nepal, Chirag; Previti, A. Christopher; Karlsen, Bård Ove; Moum, Truls; Skage, Morten; Berg, Paul Ragnar; Gjøen, Tor; Kuhl, Heiner; Thorsen, Jim; Malde, Ketil; Reinhardt, Richard; Du, Lei; Johansen, Steinar Daae; Searle, Steve; Lien, Sigbjørn; Nilsen, Frank; Jonassen, Inge; Omholt, Stig W; Stenseth, Nils Christian; Jakobsen, Kjetill Sigurd (Journal article; Tidsskriftartikkel; Peer reviewed, 2011-08-10)
      Atlantic cod (Gadus morhua) is a large, cold-adapted teleost that sustains long-standing commercial fisheries and incipient aquaculture1, 2. Here we present the genome sequence of Atlantic cod, showing evidence for complex thermal adaptations in its haemoglobin gene cluster and an unusual immune architecture compared to other sequenced vertebrates. The genome assembly was obtained exclusively by 454 ...

    • Genome-wide DNA methylation in saliva and body size of adolescent girls 

      Rounge, Trine Ballestad; Page, Christian; Lepistö, Maija; Ellonen, Pekka; Andreassen, Bettina K; Weiderpass, Elisabete (Journal article; Tidsskriftartikkel; Peer reviewed, 2016-10-20)
      Aim:<br>We performed an epigenome-wide association study within the Finnish Health in Teens cohort to identify differential DNA methylation and its association with BMI in adolescents.<br>Materials & methods:<br>Differential DNA methylation analyses of 3.1 million CpG sites were performed in saliva samples from 50 lean and 50 heavy adolescent girls by genome-wide targeted bisulfite-sequencing.<br> ...

    • Identifying eating habits in Finnish children: A cross-sectional study 

      De Oliveira Figueiredo, Rejane Augusta; Viljakainen, Jannina; Viljakainen, Heli; Roos, Eva; Rounge, Trine Ballestad; Weiderpass, Elisabete (Journal article; Tidsskriftartikkel; Peer reviewed, 2019-03-15)
      <p><i>Background - </i>We aimed to identify different eating habits among Finnish children and to evaluate their association with meal patterns, breakfast consumption, and socio-demographic characteristics in a large, nationwide cohort of children. <p><i>Methods - </i>We evaluated 10,569 children aged 9–14 years into the Finnish Health in Teens cohort in a cross-sectional design. The hierarchical ...

    • Mitochondrial genome variation of Atlantic cod 

      Jørgensen, Tor Erik; Karlsen, Bård Ove; Emblem, Åse; Breines, Ragna; Andreassen, morten; Rounge, Trine Ballestad; Nederbragt, Alexander Johan; Jakobsen, Kjetill Sigurd; Nymark, Marianne; Ursvik, anita; Coucheron, Dag H; Jakt, Lars Martin; Nordeide, Jarle Tryti; Moum, Truls Borg; Johansen, Steinar Daae (Journal article; Tidsskriftartikkel; Peer reviewed, 2018-06-19)
      Objective:<br> The objective of this study was to analyse intraspecifc sequence variation of Atlantic cod mitochondrial DNA, based on a comprehensive collection of completely sequenced mitochondrial genomes. <br>Results:<br> We determined the complete mitochondrial DNA sequence of 124 cod specimens from the eastern and western part of the species’ distribution range in the North Atlantic Ocean. ...

    • Picky eating - A risk factor for underweight in Finnish preadolescents 

      Viljakainen, Heli T.; Figueiredo, Rejane Augusta de Oliveira; Rounge, Trine Ballestad; Weiderpass, Elisabete (Journal article; Tidsskriftartikkel; Peer reviewed, 2018-10-25)
      <i>Background</i> - Picky eating (PE) is the most common cause of early-life feeding problems. However, the consequences of PE on food intake and weight development in general populations have not been established.<p><p> <i>Objectives</i> - This study aims to investigate the associations of PE and food neophobia (FN) with weight status in 5700 Finnish preadolescents. In addition, we described ...

    • Reproducibility and repeatability of six high-throughput 16S rDNA sequencing protocols for microbiota profiling 

      Raju, Sajan C.; Lagström, Sonja; Ellonen, Pekka; de Vos, Willem M.; Eriksson, Johan Gunnar; Weiderpass, Elisabete; Rounge, Trine Ballestad (Journal article; Tidsskriftartikkel; Peer reviewed, 2018-03-18)
      Culture-independent molecular techniques and advances in next generation sequencing (NGS) technologies make large-scale epidemiological studies on microbiota feasible. A challenge using NGS is to obtain high reproducibility and repeatability, which is mostly attained through robust amplification. We aimed to assess the reproducibility of saliva microbiota by comparing triplicate samples. The ...

    • Saliva microbiota differs between children with low and high sedentary screen times 

      Engberg, Elina; Raju, Sajan; Figueiredo, Rejane A.O.; Weiderpass, Elisabete; Rounge, Trine Ballestad; Viljakainen, Heli (Journal article; Tidsskriftartikkel; Peer reviewed, 2021-04-20)
      This study examined whether the diversity, composition and functional capacity of the saliva microbiota differed between children with low and high sedentary screen times. We analyzed the saliva microbiota using 16S rRNA (V3–V4) sequencing from 193 children with low and 183 children with high TV/screen viewing times while sitting. Microbiota diversity was higher among children with low screen ...